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Treatment of High-Risk Neuroblastoma

For information about the treatments listed below, see the Treatment Option Overview section.

Children with newly diagnosed high-risk neuroblastoma usually receive treatment in three phases: induction, consolidation, and maintenance.

Treatment during induction may include:

  • Combination chemotherapy.
  • Surgery.

Treatment during consolidation may include:

  • Two courses of high-dose combination chemotherapy followed by stem cell rescue.
  • Radiation therapy.

Treatment during maintenance may include:

  • Monoclonal antibody therapy (dinutuximab), granulocyte-macrophage colony-stimulating factor (GM-CSF), and isotretinoin.

Treatments under study may include:

  • A clinical trial of iodine 131-MIBG therapy, targeted therapy (lorlatinib), or a vaccine to treat cancer.

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

This information is not intended to replace the advice of a doctor. Navigating Care disclaims any liability for the decisions you make based on this information. This information was sourced and adapted from Adapted from the National Cancer Institute's Physician Data Query (PDQ®) Cancer Information Summaries on www.cancer.gov.

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The Navigating Care Library includes articles about cancer, chemotherapy regimens and drugs from the the National Cancer Institute and other experts.